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Dr. Ruben Mesa Discusses the COMFORT Ruxolitinib Trials

Published May 3, 2012 | By AM

Ruben A. Mesa, MD, Professor of Medicine, Chair, Division of Hematology & Medical Oncology, Mayo Clinic, Arizona, discusses the phase III Controlled Myelofibrosis Study with Oral JAK Inhibitor Treatment (COMFORT) trials, which led to the FDA approval of ruxolitinib (Jakafi) for patients with myelofibrosis. COMFORT-I was a placebo controlled studied… Continue reading →

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Insidermedicine In Depth – September 15, 2010 – Myelofibrosis Treatment

Published April 2, 2012 | By AM

An experimental new targeted therapy known as INCB018424 is showing early promise for the treatment of myelofibrosis in research published in the New England Journal of Medicine. Here is some information about myelofibrosis: • It is a bone marrow disorder that disrupts the body’s ability to produce normal blood cells… Continue reading →

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Study Finds Ruxolitinib Effective in Reducing Myelofibrosis Symptoms – Mayo Clinic

Published March 13, 2012 | By AM

Ruben Mesa, MD, hematologist at Mayo Clinic in Arizona, discusses findings from a study published in the New England Journal of Medicine which found Ruxolitinib effectively improves the quality of life and reduces symptoms for those with intermediate and advanced forms of myelofibrosis.

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    Dr. Mesa Discusses JAK Inhibitors for Myelofibrosis

    Published March 6, 2012 | By AM

    Ruben A. Mesa, MD, Professor of Medicine, Chair, Division of Hematology & Medical Oncology, Mayo Clinic, Arizona, discusses the success of JAK1 and JAK2 inhibitors for the treatment of patients with myelofibrosis, a disease in which the bone marrow is replaced by fibrous scar tissue. Inhibiting JAK pathways allows physicians… Continue reading →

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    Drug Extends Survival for Myelofibrosis Patients

    Published March 2, 2012 | By AM

    A drug that relieves the severe symptoms of a life-threatening bone marrow cancer called myelofibrosis also improves the survival of patients with the disease, according to a phase III clinical trial published in the March 1 edition of New England Journal of Medicine. “The Phase I/II clinical trial showed that… Continue reading →

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